The siege of Orléans was the final key military engagement of the first French War of Religion. Having lost the Battle of Dreux the rebel Huguenots fell back with their remaining forces to the city. François, Duke of Guise, the only non captive royal commander, moved to lay siege to the town, hoping its capitulation would bring about a total victory for the crowns forces. However, despite reducing the suburbs, he would be assassinated at the siege before he could bring it to a conclusion. As a result the captive Louis, Prince of Condé and Anne de Montmorency at Catherine de' Medici's direction were able to negotiate a compromise end to the first war in the Edict of Amboise.